2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Glycine Receptor (GlyR)

Glycine Receptor (GlyR) 

Glycine Receptor

Glycine Receptor (GlyR) is a ligand-gated chloride ion channel. GlyR can specifically bind to the neurotransmitter glycine, mediate the influx of chloride ions, thereby generating inhibitory postsynaptic potentials and regulating the excitability of neurons. GlyR can be activated by a series of simple amino acids, such as glycine, alanine, and taurine. GlyR is involved in various physiological functions such as sensory information processing, motor control, pain perception, and cognition, and plays a crucial role in the process of neural signal transmission. Abnormal functions of GlyR are associated with multiple neurodevelopment-related disorders, such as autism and epilepsy[1].

Glycine Receptor (GlyR) 相关产品 (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-106969A
    ZD 9379 sodium Antagonist
    ZD 9379 sodium 是一种竞争性甘氨酸/NMDA 受体 (glycine/NMDA receptor) 拮抗剂，IC50 (谷氨酸位点) 为 75 nM。ZD 9379 sodium 选择性拮抗 NMDA 受体上的甘氨酸结合位点 (GlyB 位点)，抑制甘氨酸与 NMDA 受体结合，缓解兴奋性毒性。ZD 9379 sodium 通过抑制皮质扩散性抑制 (SDs) 的频次，减轻缺血半暗带能量耗竭，延缓梗死扩展。ZD 9379 sodium 在小鼠模型中减少梗死体积并改善神经功能。ZD 9379 sodium 可用于急性缺血性卒中等研究。
    ZD 9379 sodium
  • HY-W975902
    MDL-27531 Agonist
    MDL-27531 在功能上类似于甘氨酸激动剂。MDL-27531 选择性地减少后肢收缩。MDL-27531 选择性地逆转士的宁诱导的小鼠癫痫发作。MDL-27531 以 55 mg/kg 的 ED50 值抑制戊四唑诱导的癫痫发作。MDL-27531 促进苯二氮卓类拮抗剂 Ro 15-1788 与小鼠大脑皮层的结合，但不改变 GABA 水平。MDL-27531 可用于反射控制功能障碍的研究。
    MDL-27531
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